Disabled macroautophagy as a hallmark of aging is like a malfunctioning garbage disposal system in your kitchen.

In our cells, there’s a process called macroautophagy that acts like a garbage disposal. It helps to remove and recycle old or damaged parts, like a disposal unit breaking down and not doing its job properly.

As we age, this cellular garbage disposal system can become less efficient or “disabled,” just like your kitchen’s disposal system may stop working correctly over time. When this happens, cellular waste can accumulate in our cells, causing problems and contributing to the aging process and age-related health issues.

So, disabled macroautophagy means that our body’s mechanism for cleaning up and recycling cellular waste becomes less effective with age, which can impact our overall health.