Resources
The Longevity Industry will be the Biggest and Most Complex Industry in Human History 1
The intensive application of AI to all stages of Longevity and Preventive Medicine R&D has the potential to rapidly accelerate the clinical translation of both validated and experimental diagnostics, prognostics and therapeutics.
Hallmarks of aging:
An expanding universe 2
Aging is driven by hallmarks fulfilling the following three premises: (1) their age-associated manifestation, (2) the acceleration of aging by experimentally accentuating them, and (3) the opportunity to decelerate, stop, or reverse aging by therapeutic interventions.
Biomarkers of ageing: Current state-of-art, challenges, and opportunities 3
Aging biomarkers are categorized based on the data sources, molecular and cellular profiles, images, clinical measures, and composite data. Molecular and cellular biomarkers are subdivided into telomere length, omics biomarkers, biophysical biomarkers, and blood profile.
DNA Methylation Clocks: Predictive Capacity for Aging Phenotypes and Healthspan 4
Comparison of chronological vs biological DNAm clocks. Chronological DNAm clocks reflect age-related DNAm changes that are shared between individuals and are expected to reflect the intrinsic aging process, biological DNAm clocks reflect age-related DNAm changes that vary between individuals.
The multifactorial nature of healthy brain ageing: Brain changes, functional decline and protective factors 5
Synopsis of changes the healthy brain endures through the lifespan, from the micro to the macroscopic level and the associated modifiable risk factors and beneficial active interventions to support a healthy ageing process.
Human age reversal: Fact or fiction? 6
Dietary, lifestyle, and pharmacological interventions reported to slow or reverse an aging clock in humans.
Novel Approaches to Enhance Healthspan Through Targeting Cellular Senescence and Related Aging Mechanisms 7
The Geroscience Hypothesis. Lifespan is a possible by-product of ↑healthspan. **Interventions targeting fundamental aging mechanisms combined with disease-specific interventions can perhaps achieve an additive or even more than additive benefit.
The economic value of targeting aging 8
Willingness to pay by year of life for Metformin treatment started at age 75. The chart shows value for each year (by age) of improvements in the incidence of various diseases under simulated impact of Metformin.
Role of the gut microbiome in chronic diseases: a narrative review 9
Schematic representation of the association of the composition of the gut microbiome and gut-derived metabolites with chronic
diseases. The solid lines represent negative associations and the dashed lines represent positive associations of the disease phenotype with gut microbes and metabolites.
Chemically induced reprogramming to reverse cellular aging 10
Transcriptomic rejuvenation by reprogramming small molecule cocktails. (A, B) Delta transcriptomic ages (tAgeΔ), as measured by a biological transcriptomic clock built on rodent and human transcriptomic data (A), or rodent data alone (B). (C) Delta ages, as measured by a chronological transcriptomic clock built using human data.
Is a Venture Studio Right for You? 11
Unlike an accelerator or incubator, a venture studio doesn’t fund existing startups. It’s a company that creates multiple start-ups in house, then finds entrepreneurs who take them over to grow them.
The Future of Aging and Longevity 12
The longevity paradigm shift…comprises a growing community of life sciences and health care and health tech companies focused on solutions that address underlying drivers of disease and aging.
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